Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo.

@article{Mathot1996PharmacokinetichaemodynamicRO,
  title={Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo.},
  author={R A Matho{\^o}t and Willem Soudijn and D. D. Breimer and Adriaan P. IJzerman and Meindert Danhof},
  journal={British journal of pharmacology},
  year={1996},
  volume={118 2},
  pages={
          369-77
        }
}
1. The purpose of the present study was to develop an experimental strategy for the quantification of the cardiovascular effects of non-selective adenosine receptor ligands at the adenosine A1 and A2a receptor in vivo. 2-Chloroadenosine (CADO) was used as a model compound. 2. Three groups of normotensive conscious rats received an short intravenous infusion of 1.4 mg kg-1 CADO during constant infusions of the A1-selective antagonist, 8-cyclopentyltheophylline (CPT; 20 micrograms min-1 kg-1… CONTINUE READING
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