Pharmacokinetic evaluation of testosterone-loaded nanocapsules in rats.

  title={Pharmacokinetic evaluation of testosterone-loaded nanocapsules in rats.},
  author={Sougata Jana and Anusuya Gangopadhaya and Benoy Brata Bhowmik and Amit Kumar Nayak and Arup Mukherjee},
  journal={International journal of biological macromolecules},
In the present work, testosterone-loaded alginate nanocapsules were prepared by in situ nanoemulsification-polymer cross-linking method. Drug loading, particle size (diameter), polydispersity index and zeta potential of these alginate nanocapsules were measured 30.22 ± 1.90%, 34.53 ± 1.72 nm, 0.22 ± 0.04 and -5 mV, respectively. The pharmacokinetic evaluation of these nanocapsules was also performed in female Sprague Dawley rats. Cmax, Tmax and AUC0-24 vales were estimated 38.63ng/ml, 2h and… CONTINUE READING

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