Pharmacokinetic enhancement of protease inhibitor therapy.

@article{King2004PharmacokineticEO,
  title={Pharmacokinetic enhancement of protease inhibitor therapy.},
  author={Jennifer Renae King and Heather E Wynn and Richard C. Brundage and E. Pi{\~n}eiro Acosta},
  journal={Clinical pharmacokinetics},
  year={2004},
  volume={43 5},
  pages={
          291-310
        }
}
Combination antiretroviral therapy with two or more protease inhibitors has become the standard of care in the treatment of HIV infection. Dual protein inhibitor (PI) regimens, such as lopinavir/ritonavir, are commonly used as initial PI therapy. As viral resistance increases and the development of mechanistically novel protease inhibitors decreases, clinicians turn to ritonavir-enhanced dual PI therapy to treat salvage patients. Potency of these combination regimens is increased while pill… CONTINUE READING
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