Pharmacokinetic drug interactions in liver disease: An update.

  title={Pharmacokinetic drug interactions in liver disease: An update.},
  author={Pietro Palatini and Sara De Martin},
  journal={World journal of gastroenterology},
  volume={22 3},
Inhibition and induction of drug-metabolizing enzymes are the most frequent and dangerous drug-drug interactions. They are an important cause of serious adverse events that have often resulted in early termination of drug development or withdrawal of drugs from the market. Management of such interactions by dose adjustment in clinical practice is extremely difficult because of the wide interindividual variability in their magnitude. This review examines the genetic, physiological, and… CONTINUE READING
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