Pharmacokinetic drug interaction studies with candesartan cilexetil.

  title={Pharmacokinetic drug interaction studies with candesartan cilexetil.},
  author={J. H. G. Jonkman and Jan Jaap van Lier and P N van Heiningen and Robert Lins and Regina Sennewald and A M H{\"o}gemann},
  journal={Journal of human hypertension},
  volume={11 Suppl 2},
The aim of this series of studies was to determine the potential for pharmacokinetic interaction between candesartan (administered orally as the prodrug candesartan cilexetil) and hydrochlorothiazide (HCTZ), nifedipine, glibenclamide, warfarin, digoxin or the components of an oral contraceptive formulation. All studies were performed in healthy volunteers using randomised, crossover or add-on study designs. Candesartan cilexetil was administered orally at doses of 8, 12 or 16 mg. The… CONTINUE READING