Pharmacokinetic disposition of sequential intravenous/oral ciprofloxacin in pediatric cystic fibrosis patients with acute pulmonary exacerbation.

@article{Rubio1997PharmacokineticDO,
  title={Pharmacokinetic disposition of sequential intravenous/oral ciprofloxacin in pediatric cystic fibrosis patients with acute pulmonary exacerbation.},
  author={Thomas T Rubio and Michael V. Miles and John T Lettieri and Robert J Kuhn and Roger M Echols and Deborah A. Church},
  journal={The Pediatric infectious disease journal},
  year={1997},
  volume={16 1},
  pages={112-7; discussion 123-6}
}
OBJECTIVE Information about the pharmacokinetics of fluoroquinolone antibiotics in high risk children is scant. This study examined the disposition of sequentially administered intravenous and oral ciprofloxacin, as well as provided dosing recommendations, for the treatment of acute pulmonary exacerbations in pediatric cystic fibrosis patients. METHODS After enrollment in a Food and Drug Administration approved protocol, the pharmacokinetic profiles of ciprofloxacin (CIP) administered to 18… CONTINUE READING