Pharmacokinetic disposition of intravenous and oral pentoxifylline in horses.

  title={Pharmacokinetic disposition of intravenous and oral pentoxifylline in horses.},
  author={Mark Crisman and Jeff R. Wilcke and L S Correll and Merita Irby},
  journal={Journal of veterinary pharmacology and therapeutics},
  volume={16 1},
The pharmacokinetics of pentoxifylline (P) and its alcohol metabolite I (MI) were determined after administration of intravenous pentoxifylline, sustained release pentoxifylline tablets (Trental), and crushed pentoxifylline tablets in corn syrup, to five healthy adult horses. Pharmacokinetics were evaluated in a model-independent manner. After intravenous administration, pentoxifylline was rapidly eliminated (mean residence time 1.09 +/- 0.67 h), had a large steady-state volume of distribution… CONTINUE READING