Pharmacokinetic differences corroborate observed low tacrolimus dosage in Native American renal transplant patients.

@article{Grover2011PharmacokineticDC,
  title={Pharmacokinetic differences corroborate observed low tacrolimus dosage in Native American renal transplant patients.},
  author={Anita Grover and Lynda Ann Frassetto and Leslie Z Benet and Harini A. Chakkera},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2011},
  volume={39 11},
  pages={2017-9}
}
We have observed in clinical practice that Native Americans require lower dosages of tacrolimus to attain similar target blood trough levels compared to whites after renal transplant. Because there are no pharmacokinetic studies of tacrolimus in this ethnic group, we investigated whether this clinical observation could be corroborated by pharmacokinetic differences between Native Americans and other ethnic and racial groups. We recruited 24 adult Native American kidney transplant recipients on… CONTINUE READING
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