Pharmacokinetic determination of ephedrine in Herba Ephedrae and Wu Tou Tang decoctions in rats using ultra performance liquid chromatography tandem mass spectrometry

@article{Zheng2012PharmacokineticDO,
  title={Pharmacokinetic determination of ephedrine in Herba Ephedrae and Wu Tou Tang decoctions in rats using ultra performance liquid chromatography tandem mass spectrometry},
  author={Zhijie Zheng and Tongmeng Yan and Weiying Chen and Ling Ye and Lan Tang and Zhongqiu Liu},
  journal={Xenobiotica},
  year={2012},
  volume={42},
  pages={775 - 783}
}
  • Zhijie Zheng, Tongmeng Yan, +3 authors Zhongqiu Liu
  • Published 2012
  • Medicine, Chemistry
  • Xenobiotica
  • A rapid and sensitive ultra performance liquid chromatography tandem mass spectrometry method was developed and validated for the determination and quantification of ephedrine in rat plasma samples. An Acquity UPLC BEH C18 column (1.7 μm, 2.1 mm × 50 mm) was used for chromatographic separation. Electrospray ionization in the positive mode was used, and the precursor-fragment ion pairs of m/z 166/148 and m/z 289/97 were adopted to characterize ephedrine and testosterone (internal standard… CONTINUE READING

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