Pharmacokinetic considerations in the haemodialysis of drugs.


Clinical pharmacists can deliver safer and more efficacious drug therapy to end-stage renal patients with knowledge and application of the pharmacokinetics of haemodialysis. The physical, chemical and pharmacokinetic properties of a drug will determine its degree of dialysability. These properties included water solubility, molecular weight, protein binding, volume of distribution, and the fraction, route and rate of drug elimination. Various dialysis-induced metabolic alterations must also be considered. With an understanding of these factors, the pharmacist can determine whether dosage adjustments are necessary and, if so, make the required calculations accurately.


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@article{Parker1982PharmacokineticCI, title={Pharmacokinetic considerations in the haemodialysis of drugs.}, author={Phillip R.L. Parker and William AE Parker}, journal={Journal of clinical and hospital pharmacy}, year={1982}, volume={7 2}, pages={87-99} }