Pharmacokinetic considerations in obesity.
@article{Blouin1999PharmacokineticCI, title={Pharmacokinetic considerations in obesity.}, author={Robert A. Blouin and Graham Warren}, journal={Journal of pharmaceutical sciences}, year={1999}, volume={88 1}, pages={ 1-7 } }
Obesity is a disease characterized as a condition resulting from the excess accumulation of body fat. In conjunction with increased stores of body fat, obesity has also been associated with increased mortality influenced by increased incidence of hypertension, atherosclerosis and coronary artery disease, diabetes, cancers of the breast, colon, prostate, endometrium, ovary, and cervix, and decreased overall survivability when compared with nonobese counterparts.1-5 As a consequence, obese…
192 Citations
Effects of Obesity on Pharmacokinetics
- Medicine, BiologyClinical pharmacokinetics
- 2000
This review analyses recent publications on several classes of drugs: antibacterials, anticancer drugs, psychotropic drugs, anticonvulsants, general anaesthetics, opioid analgesics, neuromuscular blockers, β-blockers and drugs commonly used in the management of obesity.
Effects of obesity on drug pharmacokinetics
- Medicine, Biology
- 2013
Obesity has been shown to play a central role in the metabolic syndrome, which increases the risk of developing cardiovascular disease 1.5to 3-fold and obese patients show a lower response to some antithrombotic agents which has suggested that dosage regimes should be adjusted for these subjects.
Drug disposition in obesity: toward evidence-based dosing.
- Medicine, BiologyAnnual review of pharmacology and toxicology
- 2015
Two methods to distinguish between developmental and obesity-related changes are proposed for obese children, and future research should focus on the characterization of physiological concepts to predict the optimal dose for each drug in the obese population.
The effects of obesity on drug pharmacokinetics in humans
- Medicine, BiologyExpert opinion on drug metabolism & toxicology
- 2011
This review presents material describing physiological changes that occur in the obese and their relationship to body composition, and various dosing metrics currently used to scale for size, and relationships between body composition and pharmacokinetic parameters.
Effect of Obesity on the Pharmacokinetics of Drugs in Humans
- Medicine, BiologyClinical pharmacokinetics
- 2010
Clinicians should design treatment regimens that account for any significant differences in the CL and Vd in the obese, using a size descriptor that corrects for differences in absolute CL between obese and non-obese individuals.
Characterizing Pharmacokinetics in Children With Obesity—Physiological, Drug, Patient, and Methodological Considerations
- Medicine, BiologyFrontiers in Pharmacology
- 2022
Key considerations related to physiology, drug parameters, patient factors, and methodology that need to be accounted for while studying the influence of obesity on pharmacokinetics in children are highlighted and discussed.
Effects of obesity on liver cytochromes P450 in various animal models.
- Biology, MedicineBiomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
- 2017
Results reported by various authors suggest that obesity is associated with a decrease of CYP activities, and the only exception is mouse obesity induced by monosodium glutamate (administered to newborn mice) as it usually leads to increased CYP expression.
Special Populations: Profiling the Effect of Obesity on Drug Disposition and Pharmacodynamics
- Medicine, BiologyDrug Discovery and Evaluation: Methods in Clinical Pharmacology
- 2020
This chapter is a review of the available literature assessing the effects of obesity on the disposition and pharmacodynamics of some of the most commonly prescribed drugs and careful clinical decision making should always be used when applying literature from the population to individual patients and scenarios.
Pharmacokinetic Parameter Changes Observed in Obese Patients Changes Observed in Bariatric Surgery Patients
- Medicine
- 2013
With an increasing prevalence of obesity, VTE, and ACS, more obese patients are being initiated on anticoagulant pharmacotherapy than ever before and this may be partly attributed to the development of a pro-inflammatory and prothrombotic state in obese patients.
Drug pharmacokinetics in the obese population: challenging common assumptions on predictors of obesity-related parameter changes
- Medicine, BiologyExpert opinion on drug metabolism & toxicology
- 2022
Clinical studies should focus on quantifying the impact of duration and severity of obesity on drug PK in adults and adolescents, and also include oral bioavailability and pharmacodynamics in these studies.
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