Pharmacokinetic considerations for antimicrobial therapy in patients receiving renal replacement therapy.

@article{Pea2007PharmacokineticCF,
  title={Pharmacokinetic considerations for antimicrobial therapy in patients receiving renal replacement therapy.},
  author={Federico Pea and Pierluigi Viale and Federica Pavan and Mario Furlanut},
  journal={Clinical pharmacokinetics},
  year={2007},
  volume={46 12},
  pages={997-1038}
}
Continuous renal replacement therapy (CRRT), particularly continuous venovenous haemofiltration (CVVH) and continuous venovenous haemodiafiltration (CVVHDF), are gaining increasing relevance in routine clinical management of intensive care unit patients. The application of CRRT, by leading to extracorporeal clearance (CL(CRRT)), may significantly alter the pharmacokinetic behaviour of some drugs. This may be of particular interest in critically ill patients presenting with life-threatening… CONTINUE READING
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