Pharmacokinetic comparison of etilefrine to its prodrug, the stearic acid ester of etilefrine.

Abstract

The relative bioavailability of a prodrug of etilefrine, its stearic acid ester, was determined by means of plasma levels and renal excretion. The comparison of the plasma levels and renal excretion was carried out in a cross-over design in six subjects. 3H-etilefrine (20 mg) and 3H-2-etylamino-1-(3-stearoylphenyl)ethanol hydrochloride (44.42 mg) were… (More)

Topics

  • Presentations referencing similar topics