Pharmacokinetic comparison of amlodipine adipate/valsartan fixed-dose combination with amlodipine besylate/valsartan fixed-dose combination in healthy volunteers.

  title={Pharmacokinetic comparison of amlodipine adipate/valsartan fixed-dose combination with amlodipine besylate/valsartan fixed-dose combination in healthy volunteers.},
  author={Jung Hyun Nam and Minkyung Oh and Hyun Ji Kim and Sungpil Han and Eun Ji Kim and Geun Seog Song and Eun-Young Kim and Jae-Gook Shin and Jong-Lyul Ghim and Ho-Sook Kim},
  journal={International journal of clinical pharmacology and therapeutics},
  volume={53 1},
  • J. Nam, M. Oh, Ho-Sook Kim
  • Published 2015
  • Medicine
  • International journal of clinical pharmacology and therapeutics
The aim of this study was to compare pharmacokinetic characteristics of fixed-dose combination (FDC) of two different salt form of amlodipine, amlodipine adipate/valsartan and amlodipine besylate/ valsartan, in healthy Korean volunteers under fasting conditions. A randomized, open-label, single-dose, two-treatment, two-way crossover study with a 14-day wash-out period was conducted. Plasma samples were collected for up to 144 hours for amlodipine and 24 hours for valsartan. Plasma… 

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