Corpus ID: 45071708

Pharmacokinetic characterization of mitonafide in man.

  title={Pharmacokinetic characterization of mitonafide in man.},
  author={E. Brode and A. Poveda Velasco and E. D{\'i}az-Rubio and R. Rosell Costa and A. Benavides Fissure},
  journal={Methods and findings in experimental and clinical pharmacology},
  volume={14 2},
  • E. Brode, A. Poveda Velasco, +2 authors A. Benavides Fissure
  • Published 1992
  • Medicine
  • Methods and findings in experimental and clinical pharmacology
  • The pharmacokinetic behavior of mitonafide after intravenous administration (1 h infusions) to patients (118-180 mg/m2) can be described by an open three compartment body model. Mitonafide distributes quasi-instantaneously in a central distribution volume of 102 l/m2 (median) from which it equilibrates with two peripheral compartments of 106 and 258 l/m2, respectively. Its disappearance from plasma is triexponential with half-lives of 0.28, 2.0 and 26.9 h, resulting in a clearance of 69 l/h/m2… CONTINUE READING