• Corpus ID: 45071708

Pharmacokinetic characterization of mitonafide in man.

@article{Brode1992PharmacokineticCO,
  title={Pharmacokinetic characterization of mitonafide in man.},
  author={E. Brode and A. Poveda Velasco and Eduardo D{\'i}az-Rubio and R Rosell Costa and A Benavides Fissure},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={1992},
  volume={14 2},
  pages={
          131-40
        }
}

• E. Brode, A. Poveda Velasco, +2 authors A. Benavides Fissure
• Published 1 March 1992
• Medicine
• Methods and findings in experimental and clinical pharmacology

The pharmacokinetic behavior of mitonafide after intravenous administration (1 h infusions) to patients (118-180 mg/m2) can be described by an open three compartment body model. Mitonafide distributes quasi-instantaneously in a central distribution volume of 102 l/m2 (median) from which it equilibrates with two peripheral compartments of 106 and 258 l/m2, respectively. Its disappearance from plasma is triexponential with half-lives of 0.28, 2.0 and 26.9 h, resulting in a clearance of 69 l/h/m2. This clearance is mainly due to the biotransformation of mitonafide leading among others to amonafide, N-acetyl-amonafide, and N-desmethyl-amonafide, which build up substantial concentrations in plasma. Their quantitative importance in terms of exposures (AUC) relative to the parent compound are 86, 197 and 28%, respectively. Terminal elimination from plasma proceeds with half-lives of 34.3, 17.6 and 27.5 h.