Pharmacokinetic characteristics of intravenous ceftriaxone in normal adults.

  title={Pharmacokinetic characteristics of intravenous ceftriaxone in normal adults.},
  author={A A Pollock and P E Tee and Indravadan H. Patel and J R Spicehandler and Michael S. Simberkoff and James J. Rahal},
  journal={Antimicrobial agents and chemotherapy},
  volume={22 5},
The multiple-dose pharmacokinetics and tolerance of intravenous ceftriaxone were investigated in 44 adults with normal renal function. Doses of 0.5, 1.0, and 2.0 g every 12 h and 2 g every 24 h were administered intravenously at a constant rate over 30 min. Plasma and urine samples were collected after the first (day 1) and last (day 4) dose and assayed for ceftriaxone by high-pressure liquid chromatography. Considering all four doses, mean peak plasma concentrations ranged from 79 to 255… CONTINUE READING


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