Pharmacokinetic characteristics and tolerability of a novel intravenous immunoglobulin preparation

@article{Thrmann1995PharmacokineticCA,
  title={Pharmacokinetic characteristics and tolerability of a novel intravenous immunoglobulin preparation},
  author={Petra A. Th{\"u}rmann and C. Sonnenburg-Chatzopoulos and Reinhard Lissner},
  journal={European Journal of Clinical Pharmacology},
  year={1995},
  volume={49},
  pages={237-242}
}
In two independent trials 10 and 12 healthy volunteers received the novel intravenous immunoglobulin (IVIG) preparations BT 511 and BT 507, respectively. BT 511 contains 5 g human plasma proteins per 100 ml, more than 95% of which are immunoglobulins of the G class (IgG). BT 507 contains in addition 61 IU antibody against hepatitis B surface antigen (anti-HBs)·ml−1. In trial I volunteers received 4.0 ml/kg (n+4) and 8.0 ml·kg−1 (n+6) BT 511 to study the tolerability and the magnitude of the… CONTINUE READING

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