Pharmacokinetic characteristics and tolerability of a novel intravenous immunoglobulin preparation

  title={Pharmacokinetic characteristics and tolerability of a novel intravenous immunoglobulin preparation},
  author={Petra A. Th{\"u}rmann and C. Sonnenburg-Chatzopoulos and Reinhard Lissner},
  journal={European Journal of Clinical Pharmacology},
In two independent trials 10 and 12 healthy volunteers received the novel intravenous immunoglobulin (IVIG) preparations BT 511 and BT 507, respectively. BT 511 contains 5 g human plasma proteins per 100 ml, more than 95% of which are immunoglobulins of the G class (IgG). BT 507 contains in addition 61 IU antibody against hepatitis B surface antigen (anti-HBs)·ml−1. In trial I volunteers received 4.0 ml/kg (n+4) and 8.0 ml·kg−1 (n+6) BT 511 to study the tolerability and the magnitude of the… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 21 references

Struktur und biologische Eigenschaften von Immunglobulinen

A Morell, F Skavril
II. Eigenschaften von 7Globulin-Prfiparaten Schweiz Med Wochenschr • 1980
View 4 Excerpts
Highly Influenced

IgG-Subklassen der menschlichen Immunglobuline, 1st edn

A Morell, F Skavril, S Barandun
View 5 Excerpts
Highly Influenced

Metabolism of immunoglobulins.

Progress in allergy • 1969
View 4 Excerpts
Highly Influenced

Pharmacokinetic and pharmacodynamic data analysis system for the PC

G Heinzel, R Wolosczak, P TOPFIT.Thomann
View 1 Excerpt

Validation of virus removal and inactivation procedures . III / 8115 / 89 - EN - Final 1991

K Feiden

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