Pharmacokinetic characteristics and therapeutic effects of mitomycin C-dextran conjugates after intratumoural injection.

@article{Nomura1998PharmacokineticCA,
  title={Pharmacokinetic characteristics and therapeutic effects of mitomycin C-dextran conjugates after intratumoural injection.},
  author={Tomohiko Nomura and Akira Saikawa and Shiho Morita and T Sakaeda Kakutani and Fumiyoshi Yamashita and Kumi Honda and Yoshinobu Takakura and Mitsuru Hashida},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={1998},
  volume={52 3},
  pages={239-52}
}
The pharmacokinetics and therapeutic effects of macromolecular prodrugs of mitomycin C (MMC), MMC-dextran conjugates (MMC-D) were studied after intratumoural injection in rats bearing Walker 256 carcinosarcoma. As the first step, the intratumoural disposition characteristics of these drugs were delineated in perfusion experiments employing a tissue-isolated… CONTINUE READING