Pharmacokinetic basis for nonadditivity of intraocular pressure lowering in timolol combinations.

  title={Pharmacokinetic basis for nonadditivity of intraocular pressure lowering in timolol combinations.},
  author={Vincent H L Lee and Aiwu Luo and Shao Yu Li and Samir K. Podder and Jeng Sheng Chang and Shigehiro Ohdo and George M. Grass},
  journal={Investigative ophthalmology & visual science},
  volume={32 11},
The authors determined whether the ocular absorption of topically applied timolol in the pigmented rabbit was affected significantly by coadministration with either pilocarpine or epinephrine in the same drop to explain the nonadditivity in intraocular pressure lowering (IOP) seen clinically. They instilled 25 microliters of 0.65% timolol maleate solution (equivalent to 0.5% timolol), both in the presence and absence of 2.6% pilocarpine nitrate or 1% epinephrine bitartrate, into pigmented… CONTINUE READING


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