Pharmacokinetic assessment of a five-probe cocktail for CYPs 1A2, 2C9, 2C19, 2D6 and 3A.

@article{Turpault2009PharmacokineticAO,
  title={Pharmacokinetic assessment of a five-probe cocktail for CYPs 1A2, 2C9, 2C19, 2D6 and 3A.},
  author={Sandrine Turpault and William R. Brian and Robert van Horn and Alix Santoni and Franck Poitiers and Yves Donazzolo and Xavier Boulenc},
  journal={British journal of clinical pharmacology},
  year={2009},
  volume={68 6},
  pages={928-35}
}
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT * Numerous cocktails using concurrent administration of several cytochrome P450 (CYP) isoform-selective probe drugs have been reported to investigate drug-drug interactions in vivo. * This approach has several advantages: characterize the inhibitory or induction potential of compounds in development toward the CYP enzymes identified in vitro in an in vivo situation, assess several enzymes in the same trial, and have complete in vivo information about… CONTINUE READING

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