Pharmacokinetic and safety evaluations of ketoprofen gels in subjects with adult periodontitis.

@article{Lawrence1998PharmacokineticAS,
  title={Pharmacokinetic and safety evaluations of ketoprofen gels in subjects with adult periodontitis.},
  author={Herenia Procopio Lawrence and David Paquette and Philip D. Coleridge Smith and G Maynor and Richard Wilder and Graziella L. Mann and Tatiana Binder and E S Troullos and Marian Annett and Michael M Friedman and Steven Offenbacher},
  journal={Journal of dental research},
  year={1998},
  volume={77 11},
  pages={1904-12}
}
This clinical trial used a randomized, partially double-blind, controlled parallel design to evaluate the pharmacokinetics and safety of the NSAID, ketoprofen (KTP), in gel formulations. Forty-two subjects, ages 35 to 57 years, with generalized, moderate to advanced adult periodontitis were recruited and randomized to one of 5 treatments over a 14 1/2-day treatment period: (1) 0.5% KTP gel; (2) 1.0% KTP gel; (3) 1.0% KTP alternate gel; (4) 2.0% KTP gel; and (5) 25 mg KTP capsule (positive… CONTINUE READING