Pharmacokinetic and pharmacodynamic study of amodiaquine and its two metabolites after a single oral dose in human volunteers.

@article{Laurent1993PharmacokineticAP,
  title={Pharmacokinetic and pharmacodynamic study of amodiaquine and its two metabolites after a single oral dose in human volunteers.},
  author={Florence Laurent and Sylvie Saivin and Pierre Chr{\'e}tien and Jean François Magnaval and François Peyron and A. Sqalli and Ala Eldin Tufenkji and Yvon Coulais and Hironori Baba and G{\'e}rard Campistron},
  journal={Arzneimittel-Forschung},
  year={1993},
  volume={43 5},
  pages={612-6}
}
The pharmacokinetics of amodiaquine (AQ, Flavoquine, CAS 6398-98-7) and its metabolites, mono (AQml) and bis-desethyl amodiaquine (AQm2) were investigated in 8 healthy volunteers after an oral dose of 306.2 mg of AQ. Metabolic clearance was the main AQ elimination pathway. AQ disappeared rapidly, from the plasma and blood, whereas AQml appeared rapidly in… CONTINUE READING