Pharmacokinetic and pharmacodynamic studies of the H1‐receptor antagonist hydroxyzine in the elderly

@article{Simons1989PharmacokineticAP,
  title={Pharmacokinetic and pharmacodynamic studies of the H1‐receptor antagonist hydroxyzine in the elderly},
  author={K. Simons and W. Watson and X. Chen and F. Simons},
  journal={Clinical Pharmacology & Therapeutics},
  year={1989},
  volume={45}
}
The pharmacokinetics and pharmacodynamics of the antipruritic H1‐receptor antagonist hydroxyzine hydrochloride were studied in nine healthy, fasting subjects (mean age 69.5 ± 3.7 years) who ingested a single dose of hydroxyzine syrup, 0.7 mg/kg (mean dose 49.0 ± 6.7 mg). Blood samples were collected hourly for 6 hours, every 2 hours from 6 to 12 hours, at 24 hours, and then every 24 hours for 144 hours. At these times an intradermal injection of 0.01 ml of a 0.1 mg/ml histamine phosphate… Expand
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References

SHOWING 1-10 OF 21 REFERENCES
Pharmacologic basis for developing rational drug regimens for elderly patients.
  • 27
Drug Metabolism in the Elderly
  • B. Cusack
  • Medicine
  • Journal of clinical pharmacology
  • 1988
  • 29
Drug prescribing for the elderly.
  • 103
Skin test reactivity to histamine from infancy to old age.
  • 134
Pathophysiology of pruritus.
  • K. Shanley
  • Medicine
  • The Veterinary clinics of North America. Small animal practice
  • 1988
  • 28
...
1
2
3
...