Pharmacokinetic and pharmacodynamic studies of levonorgestrel-releasing intrauterine device.

  title={Pharmacokinetic and pharmacodynamic studies of levonorgestrel-releasing intrauterine device.},
  author={Bi-lian Xiao and Lin Yan Zhou and Xinli L Zhang and M C Jia and Tapani Luukkainen and H O Allonen},
  volume={41 4},
Intrauterine devices releasing 20 micrograms/day levonorgestrel were inserted in 10 women (ages 25-34). Bleeding and spotting patterns were recorded on a menstrual card during one year of follow-up. Blood samples were collected for radioimmunoassays of LH, estradiol (E2), progesterone (P) and levonorgestrel (LNG) and for sex hormone binding globulin (SHBG) 3 times a week during the 1st month of use, and twice a week during the 6th and 12th treatment months. Among the 10 women, two experienced… CONTINUE READING


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