Pharmacokinetic and pharmacodynamic properties of a new controlled-release formulation of metoprolol: A comparison with conventional tablets

@article{Sandberg1988PharmacokineticAP,
  title={Pharmacokinetic and pharmacodynamic properties of a new controlled-release formulation of metoprolol: A comparison with conventional tablets},
  author={Anders Sandberg and Ingvar Blomqvist and Ulf Jonsson and P. Lundborg},
  journal={European Journal of Clinical Pharmacology},
  year={1988},
  volume={33},
  pages={S9-S14}
}
The pharmacokinetic and pharmacodynamic properties of a new multiple-unit, controlled-release (CR) formulation of metoprolol1 (metoprolol succinate, 95 mg once daily), which has almost constant (zero-order) release properties over most of a 24-h dose interval, have been compared with those of conventional metoprolol tablets (metoprolol tartrate, 100 mg once daily and 50 mg twice daily), in 12 healthy male volunteers. The steady-state plasma concentrations of metoprolol after five days of… CONTINUE READING
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Development of a new controlled release metoprolol

  • G Ragnarsson, A Sandberg, UE Jonsson, J Sjrgren
  • J Chromatogr
  • 1987
1 Excerpt

velopment of a new controlled release metoprolol product

  • G Ragnarsson, A Sandberg, UE Jonsson, J Sjrgren
  • Drug Dev Ind Pharm
  • 1987

Biopharmaceutic considerations in designing and evaluating novel drug delivery systems

  • JP Skelly, WH Barr
  • Clin Res Pract Drug Reg Affairs
  • 1985

Combined pharmacokinetic and pharmacodynamic studies in man of the adrenergic fl ~ - receptor antagonist metoproloL

  • G Johsson
  • Acta Pharmacol Toxicol
  • 1975

Combined pharmacokinetic and pharmacodynamic studies in man of the adrenergic fl~-receptor antagonist

  • G Johsson, C-G Regrdh, L S61veI
  • metoproloL Acta Pharmacol Toxicol 36 (Copenh…
  • 1975
1 Excerpt

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