Pharmacokinetic and pharmacodynamic interactions of morin and cyclosporin.

  title={Pharmacokinetic and pharmacodynamic interactions of morin and cyclosporin.},
  author={S H Fang and Y Y Hou and Pei-dawn Lee Chao},
  journal={Toxicology and applied pharmacology},
  volume={205 1},
Morin is a flavonoid present in mulberry and herbs. We have reported that morin exerted anti-inflammatory activity on the activated macrophages. Cyclosporin (CsA) is a potent immunosuppressive agent with narrow therapeutic range, which is widely used for the treatments of autoimmune diseases and transplantation rejection. This study aimed to measure the effects of morin on the disposition of CsA in lymphoid and non-lymphoid tissues, and on the functions of immune cells in mice. CsA (Neoral, 10… CONTINUE READING
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