Pharmacokinetic and pharmacodynamic interaction of nadolol with itraconazole, rifampicin and grapefruit juice in healthy volunteers.

@article{Misaka2013PharmacokineticAP,
  title={Pharmacokinetic and pharmacodynamic interaction of nadolol with itraconazole, rifampicin and grapefruit juice in healthy volunteers.},
  author={Shingen Misaka and Nozomu Miyazaki and Midori Sasaki Yatabe and Tomoyuki Ono and Yayoi Shikama and Tetsuhito Fukushima and Junko Kimura},
  journal={Journal of clinical pharmacology},
  year={2013},
  volume={53 7},
  pages={738-45}
}
To evaluate effects of itraconazole, rifampicin and grapefruit juice on pharmacokinetics and pharmacodynamics of a hydrophilic non-selective β-adrenoceptor blocker nadolol, we conducted an open-label, four-way crossover study in 10 healthy male volunteers. A single oral dose of 30 mg nadolol was administered with water (control), itraconazole (100 mg), or… CONTINUE READING