Pharmacokinetic and pharmacodynamic features of dapoxetine, a novel drug for ‘on‐demand’ treatment of premature ejaculation

@article{Andersson2006PharmacokineticAP,
  title={Pharmacokinetic and pharmacodynamic features of dapoxetine, a novel drug for ‘on‐demand’ treatment of premature ejaculation},
  author={Karl Erik Andersson and John P. Mulhall and Michael Grant Wyllie},
  journal={BJU International},
  year={2006},
  volume={97}
}
Associate Editor 
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TLDR
There are limited data on the treatment satisfaction with dapoxetine in patients with premature ejaculation (PE) and its use in clinical practice is unclear. Expand
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TLDR
Dapoxetine is the only SSRI specifically designed to treat PE, the most common sexual dysfunction in men, and has a negative impact on interpersonal relationships. Expand
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The ideal treatment for premature ejaculation – the most common male sexual dysfunction – would be an approved, discreet and on‐demand therapy that is effective from the first dose and has noExpand
Randomized Clinical Trial Between Fluoxetine and Dapoxetine for Premature Ejaculation and Its Effect on Marital Relationship
Current evidence postulates that PE is a neurobiological phenomenon.9 The process of ejaculation is centrally regulated by inter-connected cerebral sensory areas and motor centres involving a rangeExpand
The role of local anaesthetics in premature ejaculation
TLDR
The largest ever study of its kind has been conducted on the role of language and culture in the development of Alzheimer's disease and its effects on memory and language impairment. Expand
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TLDR
Dapoxetine 60mg given as needed over 12 wk significantly prolonged the stopwatch-assessed intravaginal ejaculatory latency time (IELT) from 0.91min at baseline to 3.32min ( p p ) in two placebo-controlled phase 3 trials involving >2600 men with PE. Expand
MP48-18 COMPARISON OF PAROXETINE AND DAPOXETINE, A NOVEL SELECTIVE SEROTONIN REUPTAKE INHIBITOR, IN THE TREATMENT OF PREMATURE EJACULATION
TLDR
Early ejaculation is the most common sexual dysfunction in men and has a general prevalence rate of between 20 and 40%, and an inability to delay ejaculation on all or nearly all vaginal penetrations. Expand
Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation
TLDR
This review addresses the definition, classification, diagnosis, physiology, and neurobiopathology of PE, and evaluates therapeutic strategies with novel treatments for PE and identifies dapoxetine as a short-acting SSRI developed specifically for the treatment of PE. Expand
Discontinuation of Dapoxetine Treatment in Patients With Premature Ejaculation: A 2-Year Prospective Observational Study
TLDR
The treatment discontinuation rate of dapoxetine was very high and patients with acquired PE, with intravaginal ejaculation latency time longer than 2 minutes before treatment, on phosphodiesterase type 5 inhibitors, and with IIEF erectile function scores lower than 26 tended to discontinue early and thus exhibited high dropout rates. Expand
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