Pharmacokinetic and pharmacodynamic evaluation of two dosing regimens for piperacillin-tazobactam.


STUDY OBJECTIVE To compare the pharmacokinetic and pharmacodynamic profiles of two dosing regimens for piperacillin-tazobactam against commonly encountered pathogens. The regimens compared were piperacillin 4.0 g-tazobactam 0.5 g administered every 8 hours, and piperacillin 3.0 g-tazobactam 0.375 g administered every 6 hours. DESIGN Multiple-dose, open… (More)


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