Pharmacokinetic and pharmacodynamic efficacy of intrapulmonary administration of ciprofloxacin for the treatment of respiratory infections.

@article{Chono2007PharmacokineticAP,
  title={Pharmacokinetic and pharmacodynamic efficacy of intrapulmonary administration of ciprofloxacin for the treatment of respiratory infections.},
  author={Sumio Chono and Tomoharu Tanino and Toshinobu Seki and Kazuhiro Morimoto},
  journal={Drug metabolism and pharmacokinetics},
  year={2007},
  volume={22 2},
  pages={
          88-95
        }
}
The pharmacokinetic and pharmacodynamic efficacy of intrapulmonary administration of ciprofloxacin (CPFX) for the treatment of respiratory infections caused by pathogenic microorganisms resisting sterilization systems of alveolar macrophages (AMs) was evaluated by comparison with an oral administration. The time-courses of the concentration of CPFX in AMs and lung epithelial lining fluid (ELF) following intrapulmonary administration of CPFX solution to rats (200 microg/kg) were markedly higher… CONTINUE READING
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