Pharmacokinetic and pharmacodynamic considerations in the development of therapeutic proteins.

@article{Mahmood2005PharmacokineticAP,
  title={Pharmacokinetic and pharmacodynamic considerations in the development of therapeutic proteins.},
  author={Iftekhar Mahmood and Martin David Green},
  journal={Clinical pharmacokinetics},
  year={2005},
  volume={44 4},
  pages={331-47}
}
With an increasing number of therapeutic proteins moving into preclinical and clinical development, pharmacokinetic factors play an important role in the development of these macromolecules. It is also important that the pharmacokinetic evaluation of these compounds be done as accurately as possible. For macromolecules, evaluation of pharmacokinetic parameters is often complicated by a number of factors. Bioanalytical methods are essential for any pharmacokinetic study, but for many therapeutic… CONTINUE READING

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