Pharmacokinetic and pharmacodynamic characteristics and safety of inhaled albuterol enantiomers in healthy volunteers.

Abstract

The pharmacokinetics and pharmacodynamics of inhaled albuterol given as single or multiple doses of racemate (RS-) or single enantiomers (R-, S-) were determined. In an open-label, three-way crossover, parallel-dose study, 1.25 and 5 mg of (R)- and (S)-albuterol and 2.5 and 10 mg of (RS)-albuterol were given via nebulization to 15 healthy volunteers. The… (More)

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@article{GumbhirShah1998PharmacokineticAP, title={Pharmacokinetic and pharmacodynamic characteristics and safety of inhaled albuterol enantiomers in healthy volunteers.}, author={Kavita Gumbhir-Shah and David Kellerman and S T Degraw and P. Koch and William Jusko}, journal={Journal of clinical pharmacology}, year={1998}, volume={38 12}, pages={1096-106} }