Pharmacokinetic and pharmacodynamic changes in the elderly. Clinical implications.

  title={Pharmacokinetic and pharmacodynamic changes in the elderly. Clinical implications.},
  author={A H{\"a}mmerlein and Hartmut Derendorf and David T. Lowenthal},
  journal={Clinical pharmacokinetics},
  volume={35 1},
Age-related changes in pharmacokinetics principally affect drug absorption, distribution, metabolism and elimination. Changes in pharmacodynamics are primarily seen in the cardiovascular and neuroendocrine system. Age-dependent changes in the kinetics and dynamics of drugs acting on the cardiovascular system and central nervous system are common, and this review, while by no means exhaustive of the effects of drugs on all organ systems, is reflective of the principles and gives examples of the… CONTINUE READING


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