Pharmacokinetic and pharmacodynamic basis for effective argatroban dosing in pediatrics.

@article{Madabushi2011PharmacokineticAP,
  title={Pharmacokinetic and pharmacodynamic basis for effective argatroban dosing in pediatrics.},
  author={Rajanikanth Madabushi and Donna S. Cox and Mohammad Towhid Hossain and Duane A. Boyle and Bela R. Patel and Guy Young and Young-Moon Choi and Jogarao V. S. Gobburu},
  journal={Journal of clinical pharmacology},
  year={2011},
  volume={51 1},
  pages={19-28}
}
The objective was to characterize the pharmacokinetics (PK) and pharmacodynamics (PD) of argatroban in pediatric patients and derive dosing recommendations. An open-label multicenter trial was conducted in pediatric patients (n = 18 from birth to 16 years). A population modeling approach was used to characterize pharmacokinetics and pharmacodynamics of argatroban in pediatric patients. Simulations were performed to derive a dosing regimen for pediatric patients. The estimated clearance of… CONTINUE READING

From This Paper

Topics from this paper.
17 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…