Pharmacokinetic and pharmacodynamic alterations in the Roux-en-Y gastric bypass recipients.

@article{Tandra2013PharmacokineticAP,
  title={Pharmacokinetic and pharmacodynamic alterations in the Roux-en-Y gastric bypass recipients.},
  author={Sweta Tandra and Naga Chalasani and David R. Jones and Samer G. Mattar and Stephen D. Hall and Raj Vuppalanchi},
  journal={Annals of surgery},
  year={2013},
  volume={258 2},
  pages={262-9}
}
OBJECTIVE We conducted a pharmacokinetic (PK) study and a pharmacodynamic (PD) study to assess whether Roux-en-Y gastric bypass (RYGB) surgery is associated with significant changes to PK and PD of oral medications. BACKGROUND The effect of RYGB on oral drug disposition is not well understood. METHODS An oral cocktail of probe drugs for major drug-metabolizing enzymes (caffeine, tolbutamide, omeprazole, dextromethorphan, and oral and intravenous midazolam) was administered to 18 RYGB… CONTINUE READING