Pharmacokinetic and metabolic studies of high-dose busulphan in adults

@article{Hassan1989PharmacokineticAM,
  title={Pharmacokinetic and metabolic studies of high-dose busulphan in adults},
  author={Moustapha Hassan and Gunnar {\"O}berg and H. Henrik Ehrsson and Mats Ehrnebo and Inger Wallin and Bengt Smedmyr and T. T{\"o}tterman and Staffan Eksborg and Bengt Simonsson},
  journal={European Journal of Clinical Pharmacology},
  year={1989},
  volume={36},
  pages={525-530}
}
The pharmacokinetics of high-dose busulphan was studied in adult patients with acute myeloblastic leukaemia after oral doses of 1 mg·kg−1 every 6 h for 4 days. The mean steady-state plasma concentration was 1080 ng/ml−1 during the treatment. Individual steady-state concentrations after the last dose on average were 32% lower than those predicted from total AUC measurements following the first dose. Mean elimination half-life in plasma was 2.3 h after the last dose and 3.4 h after the first dose… CONTINUE READING
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Busul - phan kinetics

  • G Vassal, A Gouyette, O Hartmann, JL Pico, J Lemerle
  • Clin Pharmacol Ther
  • 1989

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