Pharmacokinetic and concentration-effect studies with intravenous metoclopramide.

@article{Bateman1978PharmacokineticAC,
  title={Pharmacokinetic and concentration-effect studies with intravenous metoclopramide.},
  author={D. Bateman and C. Kahn and K. Mashiter and D. Davies},
  journal={British journal of clinical pharmacology},
  year={1978},
  volume={6 5},
  pages={
          401-7
        }
}
1 Pharmacokinetic and concentration-effect studies have been carried out following intravenous injection of 10 mg metoclopramide hydrochloride to seven normal male volunteers. 2 It is proposed that a two-compartment model adequately describes the disposition of the drug which is rapidly distributed (T1/2alpha = 4.9 +/- 1.1 min) and eliminated (T1/2beta = 165.7 +/- 20.2 min). Total body plasma clearance of the drug is high (10.9 +/- 1.5 ml min-1 kg-1) and approximates to liver plasma flow. 3… Expand
Single-dose pharmacokinetics of metoclopramide
TLDR
Plasma concentration-time data following i.v. administration of metoclopramide suggest that the drug occurs at higher concentrations in tissues than in plasma, and that its clearance is probably limited by liver blood flow rather than liver metabolic capacity. Expand
The pharmacokinetics of metoclopramide in man with observations in the dog.
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In the dog the metabolic fate of metoclopramide is different to man with conjugation being a minor metabolic pathway and the half-life in the dog does not appear to be dose dependent. Expand
Pharmacokinetics of metoclopramide intravenously and orally determined by liquid chromatography.
TLDR
A rapid and sensitive method, based on liquid chromatography, was used to study disposition of metoclopramide in healthy volunteers following single doses intravenously and orally as aqueous solution and a slow release tablet to suggest a first-pass elimination of 25-40%. Expand
Pharmacokinetics of metoclopramide in goats.
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The pharmacokinetics of a parenteral formulation of metoclopramide (monochloride monohydrate) were determined following single intravenous and intramuscular 0.5-mg/kg doses to two groups of 4 goats in a crossover design by a two-compartment open model with first-order absorption. Expand
Clinical Pharmacokinetics of Metoclopramide
TLDR
Preliminary studies after ‘high dose’ metoclopramide demonstrate accumulation to high plasma concentrations with linear kinetics, suggesting that current high dose regimens are unnecessarily cumbersome. Expand
Concentration effect studies with oral metoclopramide.
TLDR
It has not been possible to define a concentration-effect relationship for the action of metoclopramide on the stomach and comparison with previous results after intravenous dosing suggests that the route of administration is of major importance in determining the action. Expand
The pharmacokinetics of high dose metoclopramide in patients with neoplastic disease.
TLDR
High dose metoclopramide infusions were administered to nineteen patients with bronchial carcinoma who were receiving intravenous cyclophosphamide as single agent chemotherapy and, with the exception of two patients, were completely effective in the prevention of nausea and vomiting. Expand
Pharmacokinetics of High-Dose Metoclopramide in Cancer Patients
TLDR
Despite considerable pharmacokinetic variability, intravenous administration of high doses of metoclopramide is relatively safe due to its large therapeutic index. Expand
The pharmacokinetics of single doses of metoclopramide in renal failure
TLDR
In comparison to previous studies on normal subjects these results indicate that clearance of metoclopramide in renal failure is approximately 30% of normals. Expand
Preliminary studies of the pharmacokinetics and pharmacodynamics of prochlorperazine in healthy volunteers.
TLDR
The pharmacokinetics and pharmacodynamics of prochlorperazine were studied in healthy volunteers using a recently developed h.l.p.c. assay and the main adverse effect was akathisia which was reported by five out of eight subjects after the higher i.v. dose. Expand
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INHIBITION BY APOMORPHINE OF THE METOCLOPRAMIDE‐INDUCED CATALEPSY AND INCREASE IN STRIATAL HOMOVANILLIC ACID CONTENT
  • L. Ahtee
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1975
TLDR
It is suggested that metoclopramide produces catalepsy by blocking striatal dopamine receptors by blocking dopamine receptors in the central nervous system of rats. Expand
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