Pharmacokinetic and Pharmacodynamic Interaction Between Allopurinol and Probenecid in Patients with Gout

@article{Stocker2011PharmacokineticAP,
  title={Pharmacokinetic and Pharmacodynamic Interaction Between Allopurinol and Probenecid in Patients with Gout},
  author={Sophie Lena Stocker and Garry G Graham and Andrew J. McLachlan and Kenneth Mapson Williams and Richard Osborne Day},
  journal={The Journal of Rheumatology},
  year={2011},
  volume={38},
  pages={904 - 910}
}
Objective. To investigate the pharmacokinetic and pharmacodynamic interaction between probenecid and oxypurinol (the active metabolite of allopurinol) in patients with gout. Methods. This was an open-label observational clinical study. Blood and urine samples were collected to measure oxypurinol and urate concentrations. We examined the effects of adding probenecid to allopurinol therapy upon plasma concentrations and renal clearances of urate and oxypurinol. Results. Twenty patients taking… 

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