Pharmacokinetic and Pharmacodynamic Evaluation of the Drug‐Drug Interaction Between Isavuconazole and Warfarin in Healthy Subjects

@inproceedings{Desai2017PharmacokineticAP,
  title={Pharmacokinetic and Pharmacodynamic Evaluation of the Drug‐Drug Interaction Between Isavuconazole and Warfarin in Healthy Subjects},
  author={Amit Desai and Takao Yamazaki and Albert J. Dietz and Donna L. Kowalski and Christopher Lademacher and Helene Pearlman and Shahzad Akhtar and Robert Townsend},
  booktitle={Clinical pharmacology in drug development},
  year={2017}
}
This phase 1 trial evaluated pharmacokinetic and pharmacodynamic interactions between the novel triazole antifungal agent isavuconazole and warfarin in healthy adults. Multiple doses of isavuconazole were administered as the oral prodrug, isavuconazonium sulfate (372 mg 3 times a day for 2 days loading dose, then 372 mg once daily thereafter; equivalent to… CONTINUE READING