Pharmacokinetic and Pharmacodynamic Considerations When Treating Patients with Sepsis and Septic Shock

@article{Paepe2002PharmacokineticAP,
  title={Pharmacokinetic and Pharmacodynamic Considerations When Treating Patients with Sepsis and Septic Shock},
  author={Peter de Paepe and Frans M. Belpaire and Walter Buylaert},
  journal={Clinical Pharmacokinetics},
  year={2002},
  volume={41},
  pages={1135-1151}
}
Sepsis and septic shock are accompanied by profound changes in the organism that may alter both the pharmacokinetics and the pharmacodynamics of drugs. This review elaborates on the mechanisms by which sepsis-induced pathophysiological changes may influence pharmacological processes.Drug absorption following intramuscular, subcutaneous, transdermal and oral administration may be reduced due to a decreased perfusion of muscles, skin and splanchnic organs. Compromised tissue perfusion may also… 

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...

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