Corpus ID: 21817492

Pharmacokinetic analysis of the metabolism of cocaine to norcocaine and N-hydroxynorcocaine in mice.

@article{Boyer1992PharmacokineticAO,
  title={Pharmacokinetic analysis of the metabolism of cocaine to norcocaine and N-hydroxynorcocaine in mice.},
  author={C. Boyer and D. Petersen},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1992},
  volume={20 6},
  pages={
          863-8
        }
}
  • C. Boyer, D. Petersen
  • Published 1992
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological fate of chemicals
Cocaine is hepatotoxic in humans and is a very effective hepatotoxin in the mouse. Previous in vitro studies have shown that the mixed function oxidase system is very important in the metabolism of cocaine to the hepatotoxic species. Activation of cocaine to the cytotoxic species is thought to proceed through the N-demethylation and subsequent N-hydroxylation of the bridgehead amine. The in vivo metabolism of cocaine involves not only oxidative but also hydrolytic mechanisms. Therefore the… Expand
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