Pharmacokinetic analysis of the interaction between dicoumarol and tolbutamide in man

Abstract

The effect of repeated administration of tolbutamide on the elimination and anticoagulant action of a single oral dose of dicoumarol 600 mg was studied in four healthy male subjects using a crossover design. In all subjects the plasma concentration of dicoumarol in the postabsorptive phase was lower during concomitant tolbutamide treatment. However, the… (More)
DOI: 10.1007/BF00565625

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