Pharmacokinetic analysis of [18F]FAZA in non-small cell lung cancer patients

  title={Pharmacokinetic analysis of [18F]FAZA in non-small cell lung cancer patients},
  author={Eline E Verwer and Floris H. P. van Velden and Idris Bahce and Maqsood Yaqub and Robert C. Schuit and Albert D. Windhorst and Pieter G. H. M. Raijmakers and Adriaan A. Lammertsma and Egbert F. Smit and Ronald Boellaard},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
[18F]Fluoroazomycin arabinoside (FAZA) is a positron emission tomography (PET) tracer developed to enable identification of hypoxic regions within a tumour. The aims of this study were to determine the optimal kinetic model along with validation of using alternatives to arterial blood sampling for analysing [18F]FAZA studies and to assess the validity of simplified analytical methods. Dynamic 70-min [18F]FAZA PET/CT scans were obtained from nine non-small cell lung cancer patients. Continuous… CONTINUE READING


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