Pharmacokinetic Study of an Iridoid Glucoside: Aucubin

@article{Suh2004PharmacokineticSO,
  title={Pharmacokinetic Study of an Iridoid Glucoside: Aucubin},
  author={N. Suh and C. Shim and Min Hwa Lee and S. K. Kim and I. Chang},
  journal={Pharmaceutical Research},
  year={2004},
  volume={8},
  pages={1059-1063}
}
Aucubin, a promising hepatoprotecting iridoid glucoside, was given intravenously (iv), orally (po), intraperitoneally (ip), and hepatoportally (pv) to rats. A linear pharmacokinetic behavior was obtained after iv administration of 40–400 mg/kg of aucubin. The half-life of aucubin in the postdistributive phase (t1/2,β), total-body plasma clearance (CLt), and volume of distribution (Vdss) were 42.5 min, 7.2 ml/min/kg, and 346.9 ml/kg, respectively, for a 40 mg/kg dose. There was no significant… Expand
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