Pharmacokinetic Properties and Tolerability of Cycloserine Following Oral Administration in Healthy Chinese Volunteers: A Randomized, Open-Label, Single- and Multiple-Dose 3-Way Crossover Study.

@article{Zhou2015PharmacokineticPA,
  title={Pharmacokinetic Properties and Tolerability of Cycloserine Following Oral Administration in Healthy Chinese Volunteers: A Randomized, Open-Label, Single- and Multiple-Dose 3-Way Crossover Study.},
  author={H. Zhou and Guo-lan Wu and Xingjiang Hu and Meixiang Zhu and You Zhai and J. Liu and J. Shentu and Lihua Wu},
  journal={Clinical therapeutics},
  year={2015},
  volume={37 6},
  pages={
          1292-300
        }
}
PURPOSE A new generic formulation of cycloserine has been developed in China but the pharmacokinetic properties of cycloserine in the Chinese population have not been reported. The aim of our study was to evaluate the pharmacokinetic properties and tolerability of single and multiple oral administrations of cycloserine capsules in healthy Chinese volunteers. METHODS This open-label, single- and multiple-dose 3-way crossover study was conducted in healthy Chinese volunteers. Subjects were… Expand
Pharmacokinetic Modeling, Simulation, and Development of a Limited Sampling Strategy of Cycloserine in Patients with Multidrug-/Extensively Drug-Resistant Tuberculosis
TLDR
This study showed that the AUC 0–24 h of cycloserine can be estimated in patients with multidrug-/extensively drug-resistant tuberculosis using a 1- or 2-point limited sampling strategy in combination with the developed population pharmacokinetic model. Expand
Cycloserine Population Pharmacokinetics and Pharmacodynamics in Patients with Tuberculosis
TLDR
The current dosing for cycloserine, 250 to 500 mg once or twice daily, is not sufficient for MICs of >16mg/liter, and dividing the dose minimally affected the PK/PD breakpoints while optimizing exposure, which can potentially reduce adverse drug effects. Expand
Comparison of DOS and Windows version of the MwPharm - a pharmacokinetic software for PK/PD monitoring of digoxin
TLDR
The aim of this study was to compare the usefulness of DOS and Windows version (WIN) of the MwPharm, and their prediction quality in TDM of digoxin. Expand

References

SHOWING 1-10 OF 16 REFERENCES
Bioequivalence assessment of closerin capsule to dura seromycin capsule of cycloserine after a single oral dose administration to healthy male volunteers.
  • Y. Kim, Y. J. Lee, +5 authors M. Lee
  • Medicine
  • International journal of clinical pharmacology and therapeutics
  • 2000
TLDR
The results indicate that the 2 medications of cycloserine are bioequivalent and, thus, may be prescribed interchangeably. Expand
Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis.
TLDR
Noninferiority for these regimens was not shown, which indicates that shortening treatment to 4 months was not effective in this setting, and the two moxifloxacin-containing regimens produced a more rapid initial decline in bacterial load, as compared with the control group. Expand
A four-month gatifloxacin-containing regimen for treating tuberculosis.
TLDR
Noninferiority of the 4-month regimen to the standard regimen with respect to the primary efficacy end point was not shown, and there was no evidence of increased risks of prolongation of the QT interval or dysglycemia with the 4 month regimen. Expand
High-dose rifapentine with moxifloxacin for pulmonary tuberculosis.
TLDR
The 6-month regimen that included weekly administration of high-dose rifapentine and moxifloxacin was as effective as the control regimen and the 4- month regimen was not noninferior to thecontrol regimen. Expand
Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 2: second line drugs.
TLDR
The general mechanism of action, absorption, metabolization, and excretion of the drugs used to treat multidrug resistant tuberculosis (aminoglycosides, fluoroquinolones, cycloserine/terizidone, ethionamide, capreomycin, and para-aminosalicylic acid) are described. Expand
Pharmacokinetics of Cycloserine under Fasting Conditions and with High‐Fat Meal, Orange Juice, and Antacids
TLDR
The effect of a high‐fat meal, orange juice, and antacids on absorption of a single oral dose of cycloserine and to estimate its population pharmacokinetic parameters are determined. Expand
WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update
TLDR
The guidelines promote the early use of antiretroviral agents for TB patients with HIV on second-line drug regimens and systems that primarily employ ambulatory models of care are recommended over others based mainly on hospitalisation. Expand
Development and validation of a selective and sensitive LC-MS/MS method for determination of cycloserine in human plasma: application to bioequivalence study.
TLDR
The method was successfully applied to a bioequivalence study of 250 mg cycloserine capsule formulation in 24 healthy Indian male subjects under fasting condition and was fully validated for its selectivity, interference check, sensitivity, carryover check, linearity, precision and accuracy, reinjection reproducibility, recovery, matrix effect, ion suppression/enhancement, stability and dilution integrity. Expand
Shortening treatment for tuberculosis--to basics.
TLDR
In the absence of a vaccine to provide long-term protection, control of drug-susceptible tuberculosis is largely dependent on a standard 6-month chemotherapy regimen that has been in use for more than three decades. Expand
The 2011 update of the World Health Organization guidelines for the programmatic management of drug-resistant tuberculosis
TLDR
The guidelines provide recommendations about the early use of anti-retroviral agents for TB patients with HIV who are on second-line TB drug regimens and systems that primarily employ ambulatory models of care to manage MDR-TB patients are recommended over others based mainly on hospitalization. Expand
...
1
2
...