Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide, in Human Volunteers

@article{Gobburu1999PharmacokineticPharmacodynamicMO,
  title={Pharmacokinetic-Pharmacodynamic Modeling of Ipamorelin, a Growth Hormone Releasing Peptide, in Human Volunteers},
  author={Jogarao V. S. Gobburu and Henrik Agers\o and William J. Jusko and Lars Ynddal},
  journal={Pharmaceutical Research},
  year={1999},
  volume={16},
  pages={1412-1416}
}
Purpose. To examine the pharmacokinetics (PK) and pharmacodynamics (PD) of ipamorelin, a growth hormone (GH) releasing peptide, in healthy volunteers. Methods. A trial was conducted with a dose escalation design comprising 5 different infusion rates (4.21, 14.02, 42.13, 84.27 and 140.45 nmol/kg over 15 minutes) with eight healthy male subjects at each dose level. Concentrations of ipamorelin and growth hormone were measured. Results. The PK parameters showed dose-proportionality, with a short… CONTINUE READING

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