Pharmacokinetic-Pharmacodynamic Drug Interactions with HMG-CoA Reductase Inhibitors

@article{Williams2002PharmacokineticPharmacodynamicDI,
  title={Pharmacokinetic-Pharmacodynamic Drug Interactions with HMG-CoA Reductase Inhibitors},
  author={David Williams and John Feely},
  journal={Clinical Pharmacokinetics},
  year={2002},
  volume={41},
  pages={343-370}
}
The HMG-CoA reductase inhibitors (statins) are effective in both the primary and secondary prevention of ischaemic heart disease. As a group, these drugs are well tolerated apart from two uncommon but potentially serious adverse effects: elevation of liver enzymes and skeletal muscle abnormalities, which range from benign myalgias to life-threatening rhabdomyolysis. Adverse effects with statins are frequently associated with drug interactions because of their long-term use in older patients who… 
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