Pharmacokinetic Optimisation of Benzodiazepine Therapy for Acute Seizures

@article{Rey1999PharmacokineticOO,
  title={Pharmacokinetic Optimisation of Benzodiazepine Therapy for Acute Seizures},
  author={E. Rey and J. Treluyer and G. Pons},
  journal={Clinical Pharmacokinetics},
  year={1999},
  volume={36},
  pages={409-424}
}
  • E. Rey, J. Treluyer, G. Pons
  • Published 1999
  • Medicine
  • Clinical Pharmacokinetics
  • All benzodiazepines enter cerebral tissue rapidly. However, the duration of action is short for diazepam (<2 hours) and midazolam (3 to 4 hours) and longer for clonazepam (24 hours) and lorazepam (up to 72 hours), and is not correlated with the plasma concentration-time profiles of these drugs. Although a relationship between the plasma concentration of diazepam, lorazepam and midazolam and their pharmacodynamic effect has been demonstrated in healthy individuals, some caution is warranted as… CONTINUE READING
    87 Citations
    Benzodiazepines in epilepsy: pharmacology and pharmacokinetics
    • 368
    • Highly Influenced
    Intramuscular and rectal therapies of acute seizures
    • 15
    A Short Review on the Intranasal Delivery of Diazepam for Treating Acute Repetitive Seizures
    • PDF

    References

    SHOWING 1-10 OF 94 REFERENCES
    Pharmacokinetics and Clinical Use of Benzodiazepines in the Management of Status Epilepticus
    • 69
    • Highly Influential
    Clonazepam pharmacokinetics, brain uptake, and receptor interactions.
    • 44
    Midazolam. A review of its pharmacological properties and therapeutic use.
    • 323
    Brain uptake of phenytoin, phenobarbital, and diazepam.
    • 116
    CSF penetration and pharmacokinetics of midazolam
    • 10
    Clinical Pharmacokinetics of Cerebrospinal Fluid
    • 68
    Pharmacokinetics and bioavailability of midazolam in man.
    • 264
    Benzodiazepine receptor occupancy in vivo: correlation with brain concentrations and pharmacodynamic actions.
    • 93