Pharmacokinetic Optimisation of Benzodiazepine Therapy for Acute Seizures

  title={Pharmacokinetic Optimisation of Benzodiazepine Therapy for Acute Seizures},
  author={E. Rey and J. Treluyer and G. Pons},
  journal={Clinical Pharmacokinetics},
  • E. Rey, J. Treluyer, G. Pons
  • Published 1999
  • Medicine
  • Clinical Pharmacokinetics
  • All benzodiazepines enter cerebral tissue rapidly. However, the duration of action is short for diazepam (<2 hours) and midazolam (3 to 4 hours) and longer for clonazepam (24 hours) and lorazepam (up to 72 hours), and is not correlated with the plasma concentration-time profiles of these drugs. Although a relationship between the plasma concentration of diazepam, lorazepam and midazolam and their pharmacodynamic effect has been demonstrated in healthy individuals, some caution is warranted as… CONTINUE READING
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