Pharmacokinetic Modelling of 5-FU Production from Capecitabine—A Population Study in 40 Adult Patients with Metastatic Cancer

@article{Urien2005PharmacokineticMO,
  title={Pharmacokinetic Modelling of 5-FU Production from Capecitabine—A Population Study in 40 Adult Patients with Metastatic Cancer},
  author={Sa{\"i}k Urien and Keyvan Reza{\'i} and François M. Lokiec},
  journal={Journal of Pharmacokinetics and Pharmacodynamics},
  year={2005},
  volume={32},
  pages={817-833}
}
Aims: To model the biotransformation steps of 5-FU production from capecitabine and identify patient characteristics that may influence the drug disposition. Methods: Blood samples and demographic data were collected from two phase I studies in which adult patients received oral capecitabine for various malignancies. Capecitabine, 5′-deoxy-5-fluorocytidine (5′-DFCR), 5′-deoxy-5-fluorouridine (5′-DFUR) and 5-fluorouracile (5-FU) concentration-time data were analysed via a population approach… CONTINUE READING
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