Pharmacokinetic Interactions Between Alcohol and Other Drugs

@article{Fraser1997PharmacokineticIB,
  title={Pharmacokinetic Interactions Between Alcohol and Other Drugs},
  author={Alan Gordon Fraser},
  journal={Clinical Pharmacokinetics},
  year={1997},
  volume={33},
  pages={79-90}
}
  • A. Fraser
  • Published 1 August 1997
  • Medicine
  • Clinical Pharmacokinetics
SummaryThe frequent use of alcohol (ethanol) together with prescription drugs gives any described pharmacokinetic interaction significant clinical implications. The issue is both the effect of alcohol on the pharmacokinetics of various drugs and also the effect of those drugs on the pharmacokinetics of alcohol. This review discusses these pharmacokinetic interactions but also briefly describes some other effects of alcohol that are clinically relevant to drug prescribing.The use of several… 

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References

SHOWING 1-10 OF 125 REFERENCES

Effects of Ethanol on Drug and Metabolite Pharmacokinetics

TLDR
Pharmacokinetic interactions of ethanol with other drugs, including its effects upon drug metabolite disposition, are reviewed in terms of clearance concepts to help understand the mechanisms of ethanol-drug interactions.

Effects of various concomitant medications on gastric alcohol dehydrogenase and the first-pass metabolism of ethanol.

TLDR
It is concluded that many commonly used medications affect gastric ADH, but that the increase in the actual amount of alcohol absorbed is quite small, and demonstrable only under special conditions.

Interactions between alcohol and other drugs.

  • W. L. Adams
  • Medicine
    The International journal of the addictions
  • 1995
TLDR
Since alcohol is commonly used by elderly people, educating patients about the potential for these interactions should be a routine part of health care visits.

A review of the effects of moderate alcohol intake on the treatment of anxiety and mood disorders.

TLDR
There is abundant evidence that patients with mood and anxiety disorders should abstain from even moderate ethanol use, as this adversely affects their clinical course and response to treatment.

Lack of effect of H2-receptor antagonists on the pharmacokinetics of alcohol consumed after food at lunchtime.

TLDR
None of the H2-receptor antagonists had any statistically significant effects on any of the pharmacokinetic parameters for alcohol in an open, four-way cross-over study.

H2-Antagonists and Alcohol

TLDR
There are conflicting data on the existence of significant first-pass metabolism of alcohol (ethanol) in the human stomach and its inhibition by histamine H2-receptor antagonists and the significance of this interaction is not easy to resolve.

Effects of ranitidine on blood alcohol levels after ethanol ingestion. Comparison with other H2-receptor antagonists.

TLDR
Patients treated with ranitidine or cimetidine should be warned of possible functional impairments after consumption of amounts of ethanol considered safe in the absence of such therapy.

Benzodiazepines and Ethanol: Assessment of the Effects and Consequences of Psychotropic Drug Interactions

TLDR
It is suggested that the ethanol-benzodiazepine interaction is probably less important than those involving ethanol and other psychotropic drugs, such as cannabinoids, neuroleptics, stimulants, and antidepressants.
...